A renewed and improved database for the genes of the major histocompatibility complex of different animal species

10 July 2017

BPRC - 1. A renewed and improved database for the genes of the major histocompatibility complex of different animal species

Our body must recognize viruses, bacteria and parasites and distinguish these from its tissues to render the pathogens harmless without attacking the own tissues. A very complex part of the immune system is responsible for this, the major histocompatibility complex (MHC).

For the purpose of obtaining an overview and centralised naming of all MHC variants, previously a database has been established in which scientists from all over the world can integrate their mapped MHC genes from different animal species. This database has recently been updated, which also enables comparisons of MHC gene variants of different animal species. BPRC scientists are responsible for maintaining the part of the database that collects the MHC genes of various non-human primates. A description of the renewed and improved database has been published in the scientific journal Nucleic Acids Research (https://academic.oup.com/nar/article/45/D1/D860/2574177/IPD-MHC-2-0-an-improved-inter-species-database-for).