Emerging Infectious Diseases

Emerging infectious diseases pose a significant burden on global economies and public health. Often treatment of these emerging diseases is hampered by a lack of knowledge on the pathogens that cause these diseases. At the BPRC, several models of emerging infectious diseases are being set up. These models, that include Dengue and West-Nile virus, are used for exploratory research into pathogenic mechanisms and the evaluation of new vaccines and therapies against these diseases. Furthermore, the BPRC has extensive knowledge on identification of novel viruses in non-human primates.

Selected References

Characterization of novel polyomaviruses from Bornean and Sumatran orang-utans.
Groenewoud MJ, Fagrouch Z, van Gessel S, Niphuis H, Bulavaite A, Warren KS, Heeney JL, Verschoor EJ.
J Gen Virol. 2010 Mar;91(Pt 3):653-8. doi: 10.1099/vir.0.017673-0..

Molecular analysis of a novel simian virus 40 (SV40) type in rhesus macaques and evidence for double infections with the classical SV40 type.
Fagrouch Z, Karremans K, Deuzing I, van Gessel S, Niphuis H, Bogers W, Verschoor EJ.
J Clin Microbiol. 2011 Apr;49(4):1280-6. doi: 10.1128/JCM.01005-10.

Novel polyomaviruses in South American bats and their relationship to other members of the family Polyomaviridae.
Fagrouch Z, Sarwari R, Lavergne A, Delaval M, de Thoisy B, Lacoste V, Verschoor EJ.
J Gen Virol. 2012 Dec;93(Pt 12):2652-7. doi: 10.1099/vir.0.044149-0.

Vaccine-induced protection of rhesus macaques against plasma viremia after intradermal infection with a European lineage 1 strain of West Nile virus.
Verstrepen BE, Oostermeijer H, Fagrouch Z, van Heteren M, Niphuis H, Haaksma T, Kondova I, Bogers WM, de Filette M, Sanders N, Stertman L, Magnusson S, L?rincz O, Lisziewicz J, Barzon L, Palù G, Diamond MS, Chabierski S, Ulbert S, Verschoor EJ.
PLoS One. 2014 Nov 13;9(11):e112568.

Experimental infection of rhesus macaques and common marmosets with a European strain of West Nile virus.
Verstrepen BE, Fagrouch Z, van Heteren M, Buitendijk H, Haaksma T, Beenhakker N, Palù G, Richner JM, Diamond MS, Bogers WM, Barzon L, Chabierski S, Ulbert S, Kondova I, Verschoor EJ.
PLoS Negl Trop Dis. 2014 Apr 17;8(4):e2797.