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In total there are 165 English news articles.
Unfortunately, to date, it is impossible to predict the efficacy of an experimental vaccine against HIV. Animal models play an important role in the development of an anti-HIV vaccine. These models are not only important for testing the efficacy of vaccine candidates, but also provide the opportunity to explore the mechanism of protection against disease.
Prof. Dr. Ronald Bontrop, general and scientific director of the BPRC, has been invited as Raine Visiting Professor at the University of Western Australia.
Until now, little was known about the genetic variation within the great apes, due to the difficulty in obtaining samples from apes. An international group of more than 75 researchers, including BPRC staff, and conservationists have joined efforts to make a comprehensive analysis of the genetic background of these animals at the population level.
Most probably in the distant past a precursor of the HIV virus has caused high mortality among chimpanzees. Only chimpanzees with an immune system that could control the virus survived. The current chimpanzee population is descended from these ‘survivors’. Their immune system is specialized to efficiently control this type of viruses. This is in contrast to the situation in humans, where an infection with HIV almost always will cause AIDS.
The discussion on the use of primates in biomedical research and the importance of ensuring optimal animal welfare is discussed in Public Service Review ((European Science & Technology) 17 and in Science Omega Review Europe, issue 1.
Parkinson’s disease is a disorder of the central nerve system, due to a progressive loss of a specific type of nerve cells (dopamine neurons) that govern the control of movement. This situation can be mimiced in marmosets, offering the opportunity to explore new treatments for this widespread disease.
To date, there are only a handful of drugs available against malaria. Moreover, resistance to these drugs is rapidly emerging and new drugs are therefore urgently needed. Recent research has identified a promising new class of anti-malarial compounds.
In HIV infected humans, antibodies have been identified that can prevent infection in cell cultures by binding to an essential region close to the membrane of the virus. While it is highly attractive to include this part of the virus in an anti-HIV/AIDS vaccine, previous attempts to obtain similar immune responses by immunization have failed. Using llamas and a special delivery vehicle, researchers have now found ways to solve this problem.
Investigations into the total DNA (genome) of humans and animals can explain the importance of different regions of the DNA and the underlying selection pressure. A comparison of the chimpanzee and human genome has given new insights with regards to their ancestors.
F1000 is a website for which a selected group of expert scientists, highly respected in their chosen fields can recommend scientific articles of high quality. Recently, on this website, work performed at the BPRC and described in the article ‘Transgenic Fluorescent Plasmodium cynomolgi Liver Stages Enable Live Imaging and Purification of MalariaHypnozoite-Forms, Plos One, 2013, has been identified by F1000 as being of special significance in its field.