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In total there are 165 English news articles.
Malaria parasites can differ greatly from one another. This makes it difficult to develop a vaccine on the basis of a single protein. To tackle the parasite on multiple fronts, current work is focused on a combination of proteins as vaccine.
Natalizumab (Tysabri®) is an effective drug against multiple sclerosis (MS). Natalizumab prevents the infiltration of white blood cells into the brain of MS patients. It acts by binding to two protein variants: alpha4beta1 and alpha4beta7. The alpha4beta1 protein is responsible for the reduced entrance of white blood cells in the brain. The alpha4beta7 protein is mainly involved in the infiltration of white blood cells into the intestines, but the role of alpha4beta7 in the infiltration of the brain is unclear. BPRC research provides more insight.
Treatment of the malaria parasite P. vivax is complicated because the parasite forms dormant stages in the liver that can re-activate after months, sometimes even after years and cause malaria again. The course of this process is a complete mystery. By joining forces, three Dutch malaria research groups have now for the first time shown live images of these dormant parasites of a primate malaria.
The immune system is equipped for protecting the body against infection with viruses, bacteria or parasites. While most people experience the benefits of this highly complex defense system, an increasing proportion of the population suffers from the hazardous consequences of unwanted and often detrimental immune activities that can result in allergy or autoimmune-mediated inflammatory disease (AIMID) such as multiple sclerosis (MS). The early, acute phase of AIMID can be treated with reasonable success, while an effective treatment of the late, chronic phase of disease is often lacking. Researchers are looking for clues to resolve this issue.
An analysis of malaria proteins that have been sent into the red blood cell and onto the surface of the cell
In severe cases, malaria parasites can adhere to the small blood vessels in various organs, including the brain, and cause a state of coma that may eventually lead to death. The majority of deaths caused by malaria is due to this type of malaria. The mechanisms that play a role are largely unknown. Together with colleagues of Leiden University and collaborators throughout Europe, BPRC researchers are developing models to study this type of malaria.
Worldwide an estimated 170 million people are chronically infected with the hepatitis C virus (HCV) and are therefore at risk to develop liver diseases, like cirrhosis and liver cancer. The development of a chronic HCV infection is partly dependent on the genetic background of a patient, particularly near the IL-28B gene. Another important predictive marker for the development of a chronic HCV infection is the presence of high levels of the protein IP-10 in the blood of patients. Both IL-28B and IP-10 are part of the so called 'innate immune system’. Therefore it is important to determine whether these two factors are connected to eachother.
The new BPRC facilities were formally opened on Tuesday 30 October 2012. A large number of dignitaries were present representing all the major social and scientific organisations within the Netherlands.
Although monkeys often live in groups with multiple adult males, the group leader (alpha male) is responsible for most of the sexual behaviour. He achieves this by harassing copulations of lower ranking males. However, this is not beneficial for females or lower ranking males. By concealing sexual behaviour, females and subordinate males try to reduce harassment from group members. Although harassment is not frequent, it may have serious consequences such as getting injured or not being able to finish a copulation. Although harassments are infrequent, researchers from the BPRC and University of Utrecht found that not only the dominant male disrupts copulations, but also other males and females may disrupt copulations. Moreover we found that sexual behaviour is not only performed far away from the alpha male, but also from females, indicating that not only male-male but also female-female competition is an important factor shaping sexual behaviour of monkeys.
The Major Histocompatiblity Complex (MHC) plays a central role in immune responses because it can distinguish 'self’ from 'non-self’ elements (often disease causing agents) in the body. Researchers of the BPRC have studied a component of the human MHC and compared it to the same MHC component in various primate species. This enabled them to study the development of this immunologically important system during evolution.
Which cell types play a role in the disease multiple sclerosis (MS)? Why does an effective drug against MS sometimes cause serious adverse side effects? BPRC researchers are looking for answers to these questions in order to develop and optimize new therapies against MS.