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In total there are 168 English news articles.
Although monkeys often live in groups with multiple adult males, the group leader (alpha male) is responsible for most of the sexual behaviour. He achieves this by harassing copulations of lower ranking males. However, this is not beneficial for females or lower ranking males. By concealing sexual behaviour, females and subordinate males try to reduce harassment from group members. Although harassment is not frequent, it may have serious consequences such as getting injured or not being able to finish a copulation. Although harassments are infrequent, researchers from the BPRC and University of Utrecht found that not only the dominant male disrupts copulations, but also other males and females may disrupt copulations. Moreover we found that sexual behaviour is not only performed far away from the alpha male, but also from females, indicating that not only male-male but also female-female competition is an important factor shaping sexual behaviour of monkeys.
The Major Histocompatiblity Complex (MHC) plays a central role in immune responses because it can distinguish 'self’ from 'non-self’ elements (often disease causing agents) in the body. Researchers of the BPRC have studied a component of the human MHC and compared it to the same MHC component in various primate species. This enabled them to study the development of this immunologically important system during evolution.
Which cell types play a role in the disease multiple sclerosis (MS)? Why does an effective drug against MS sometimes cause serious adverse side effects? BPRC researchers are looking for answers to these questions in order to develop and optimize new therapies against MS.
Behavioral biologists from Utrecht University and BPRC, studied the contagiousness of yawning among the chimpanzee population in Burgers’ Zoo in Arnhem, the Netherlands. They showed that, as for humans, also the yawning of chimpanzees is contagious. Above all, they showed that chimpanzee male yawns are far more contagious for their conspecifics than female yawns. The study was published in PLOS One.
Some people are infected with the Human Immunodeficiency Virus (HIV) but do not get clinical symptoms. In these people, antibodies which can neutralize a broad range of HIV isolates have been detected. The breadth of this activity is important since HIV has the capacity to rapidly produce new variants. So far, attempts to mimic nature in animal models, trying to induce antibodies with similar potency and breadth, have failed.
Apical Membrane Antigen 1 (AMA1) is an important protein of the malaria parasite. This protein is regarded as a major vaccine candidate, since immunization with AMA1 has offered protection against malaria in various animal models. Researchers of the BPRC have developed the technology to produce this protein in large quantities, providing the opportunity to test the activity of this protein in humans.
Malaria parasites enter red blood cells to multiply and subsequently invade new red blood cells. This causes the disease malaria. Apical Membrane Antigen-1 (AMA-1), a protein of the malaria parasite plays an important role in the process of red blood cell invasion. Antibodies directed against AMA-1 can block invasion of red blood cells and therebye prevent disease. Therefore this protein is recognised as an important vaccine candidate against malaria.
The Council of the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC International) has awarded BPRC full accreditation.
Transplantation technologies have improved life expectancy and quality of life for a significant group of people. Current transplantation technologies are partly based on research that has been performed at the BPRC.