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In total there are 165 English news articles.
How do Epstein-Barr Virus (EBV) infected cells disrupt the immune system and thereby play a role in multiple sclerosis (MS)?
There are numerous lines of evidence indicating that there is a link between EBV infection and MS. In a marmoset monkey model for MS an infection with the `monkey-EBV` has also been shown to activate immune cells to attack the own body. Researchers at the BPRC have investigated how this (unwanted) activation can take place.
On 16 January 2017 Jaco Bakker successfully defended his thesis entitled `Veterinary care and welfare management in common marmosets`
At present we are implementing a novel integrated PET/CT scanner for refinement and enhancement of our experimental TB research capacity. In this endeavour BPRC is supported by the so-called Collaboration for Tuberculosis Vaccine Discovery (CTVD), an initiative of the Bill & Melinda Gates Foundation, and specifically also by the expert team of Prof. Dr. Flynn at the University of Pittsburgh (PA, USA), who pioneered the use PET/CT in NHP TB research.
To date there is no malaria vaccine available. The vaccine which is most advanced in development, mosquirix™ of GSK, is only protective against disease in ± 30 % of the people. Possibly protective effects can be improved by adding a component to the mosquirix vaccine.
Increased susceptibility to Alzheimer's disease in a monkey model due to activation of the immune system
There is still no treatment for Alzheimer's disease. Researchers from the BPRC have studied the influence of the immune system on the development of the disease. This could open up new possibilities for therapies.
Microglia, immune cells of the brain, appear to have been adapted to their challenging environment. They react less destructive to danger signals than their counterparts in the blood.
Currently, only a limited number of drug have known activity against malaria and in addition drug resistance is emerging. Scientists have developed an innovative method to identify new compounds that target malaria.
The intestinal flora is important for maintaining an immunological balance. This is mainly due to leakage of bacterial products through the intestinal wall rendering them visible to the immune system. This process, called microbial translocation induces a response of the immune system by producing a substance called sCD14.
The BPRC contributes to research in vaccine development and new medicines against Zika virus
We hereby present the BPRC 2015 Annual Scientific Report and show the research highlights of 2015.