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In total there are 165 English news articles.
On 18 February 2016 Babs Verstrepen successfully defended her thesis "Chronic hepatitis C virus infection in chimpanzees - prevention and consequences."
Although there has been enormous progress in the prevention and treatment of HIV/AIDS, worldwide still 35 million people are infected with HIV with ca. 6,000 new infections each day. Therefore, a vaccine is still desperately needed.
BPRC is involved in a new European research project on replacement of animal studies for vaccine batch testing.
The Major Histocompatibility Complex (MHC) is a highly complex system, which plays an important role in the recognition of pathogens. This system exhibits a high degree of variation in order to prevent elimination of an entire population by a single pathogen. A component of the MHC, the MHC class I, plays a central role in responses of the immune system against infections and cancer.
Annually, TB kills about 1.5 million people. Improved diagnostics and tools to monitor treatment effects would significantly enhance effectiveness of TB therapies.
In 1982, it was observed that MPTP, a by-product of the drug MPPP, caused early parkinsonian symptoms in drug users who had used drugs contaminated with MPTP. It is unknown how MPTP causes these symptoms. Nowadays, MPTP is used in research on Parkinson's disease.
The immune system and the physiology of rhesus and cynomolgus monkeys is very similar to that of humans. Therefore, these animals play an important role in research on the safety and efficacy of new influenza vaccines.
BPRC has been selected as one of the expert centres for the “Collaboration for Tuberculosis Vaccine Discovery” that was recently initiated by the Bill & Melinda Gates Foundation.
The HIV/AIDS pandemic originates from cross-species transmission of the AIDS virus from chimpanzees to humans. Many African monkeys are infected with SIV, but those studied in captivity generally do not develop disease. However, wild chimpanzees infected with the chimpanzee-AIDS virus are at increased risk of death and may develop an AIDS-like disease. Is this because they live in the wild, or is it due to differences between simian AIDS viruses and chimpanzee and human AIDS viruses?
Many pathogens that cause disease in humans, can also cause disease in (rhesus) monkeys and therefore monkeys play an important role as a model-species in the search for cures against these diseases. A lot of therapies involve the stimulation of the immune system in order to eliminate the presence of the pathogens. As a consequence, knowledge of the immune system of monkeys is important for this type of work. This may also aid in the selection of a minimal number of animals for experimental purposes.