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In total there are 168 English news articles.
BPRC has been selected as one of the expert centres for the “Collaboration for Tuberculosis Vaccine Discovery” that was recently initiated by the Bill & Melinda Gates Foundation.
The HIV/AIDS pandemic originates from cross-species transmission of the AIDS virus from chimpanzees to humans. Many African monkeys are infected with SIV, but those studied in captivity generally do not develop disease. However, wild chimpanzees infected with the chimpanzee-AIDS virus are at increased risk of death and may develop an AIDS-like disease. Is this because they live in the wild, or is it due to differences between simian AIDS viruses and chimpanzee and human AIDS viruses?
Many pathogens that cause disease in humans, can also cause disease in (rhesus) monkeys and therefore monkeys play an important role as a model-species in the search for cures against these diseases. A lot of therapies involve the stimulation of the immune system in order to eliminate the presence of the pathogens. As a consequence, knowledge of the immune system of monkeys is important for this type of work. This may also aid in the selection of a minimal number of animals for experimental purposes.
In the Dutch newspaper ‘Algemeen Dagblad’ of August 27 2015 BPRC director Ronald Bontrop discusses the monkey research that is performed at the BPRC.
In a mouse model for multiple sclerosis (MS), a therapeutic antibody against a substance of the immune system, IL-7, was 100% effective in preventing disease. BPRC scientists determined whether this effect could be translated to primates.
We here present the BPRC 2014 Annual Scientific Report and show especially the research highlights of the selected topic ‘Infectious Diseases’.
Malaria continues to kill up to 580.000 people each year, the majority being children under 5 years old. An effective vaccine is still lacking, and therefore efforts to combat the disease focus on insecticide-treated bed nets and drugs. Unfortunately, these efforts are threatened by emerging resistance of the parasite to current therapies.
VICE is a young medium that makes documentaries for the Internet. At the end of 2014, struck by the debate on animal testing and the BPRC, VICE came with the request to film at the BPRC facilities.
Multiple sclerosis (MS) develops exclusively in humans. Non-human primates are resistant against MS, although they seem to be highly susceptible to experimentally induced MS-like disease. Unraveling of the cause(s) underlying this discrepancy is highly relevant as insights might be gained into the elusive event(s) that trigger(s) MS.
Influenza continues to threaten a large part of the world´s population, mainly young children, elderly and people with a compromised immune system. The influenza virus differs from year to year, complicating vaccination strategies. More research is warranted to combat this important disease. BPRC researchers have characterized an influenza virus infection in different monkey species to establish a model system for influenza research that mimics the human situation.