We have developed and evaluated three non-human primate species for influenza vaccine research, i.e. rhesus and cynomolgus monkeys and common marmosets. These models offer unique possibilities to study in detail the immune mechanisms and processes involved in the protection against influenza infection. Our research focuses on protective effects of new vaccines, identification of correlates of protection and in depth analysis of mechanisms involved in protection. State-of-the art techniques, including imaging, in-depth analysis of cellular and humoral immune responses and pathological examination are readily available.
Pandemic Swine-Origin H1N1 Influenza Virus Replicates to Higher Levels and Induces More Fever and Acute Inflammatory Cytokines in Cynomolgus versus Rhesus Monkeys and Can Replicate in Common Marmosets. Mooij P, Koopman G, Mortier D, van Heteren M, Oostermeijer H, Fagrouch Z, de Laat R, Kobinger G, Li Y, Remarque EJ, Kondova I, Verschoor EJ, Bogers WM. PLoS One. 2015 May 6;10(5):e0126132