PhD awarded to Jordon Dunham at Groningen University
24 October 2017
On 18 October 2017 Jordon Dunham successfully defended his thesis entitled `Translational Multiple Sclerosis Research in Primates`.
There is still no curative therapy for multiple sclerosis (MS). In order to develop new therapies it is important to understand which processes initiate and promote the development of this disease. Animal models play a central role in the elucidation of these processes.
Jordon Dunham's research focused on the characterization of experimental induced encephalomyelitis in marmoset monkeys, an accepted animal model for MS. There are rodent models available for MS, but several important factors for MS disease progression in humans, such as brain damage by oxygen radicals, can not be studied in rodents.
The work described in the dissertation shows that several crucial processes for MS disease progression in humans are also occurring the MS marmoset model. Furthermore, this research shows that the marmoset MS model can play an important role to study the immunological mechanisms that are involved in the development of MS.