News

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In total there are 157 English news articles.

10 July 2017
A renewed and improved database for the genes of the major histocompatibility complex of different animal species

A renewed and improved database for the genes of the major histocompatibility complex of different animal species


Our body must recognize viruses, bacteria and parasites and distinguish these from its tissues to render the pathogens harmless without attacking the own tissues. A very complex part of the immune system is responsible for this, the major histocompatibility complex (MHC).

29 June 2017
BPRC ANNUAL SCIENTIFIC REPORT 2016

BPRC ANNUAL SCIENTIFIC REPORT 2016


We are pleased to present the BPRC 2016 Annual Scientific Report

20 June 2017
The Epstein Barr Virus (EBV) can deregulate the human immune system and cause disease

The Epstein Barr Virus (EBV) can deregulate the human immune system and cause disease


BPRC researchers have previously shown that an EBV-related virus can disrupt the immune system of monkeys  and can therebye cause multiple sclerosis (MS) (http://www.bprc.nl/en/article/infection-with-a-virus-related-to-epstein-barr-dysregulates-the-immune-system-of-monkeys). This work has been described  previously  in the Multiple Sclerosis Journal - Experimental, Translational and Clinical

20 June 2017
Genetic signals from the mother affect gene expression of the unborn child in the placenta

Genetic signals from the mother affect gene expression of the unborn child in the placenta


Each cell in the body contains the same DNA, the genetic code that determines which proteins may be produced by a cell. However, the proteins that are produced differ significantly between cells of different tissues. Similarly, the timing of expression and the expression levels are regulated in a complex manner at different levels. For example, certain molecules such as methyl groups can bind to specific parts of the DNA. Such genetic modification often leads to suppression of the transcription of the gene and the associated protein production.

20 June 2017
A new antimalaria drug candidate

A new antimalaria drug candidate


Currently, malaria is treated with a mixture of medicines including artemisinin, isolated from a herb that has been used for a long time in traditional Chinese medicine.

31 May 2017
A new benchmark: local mucosal immunisation improves where standard peripheral TB vaccination fails

A new benchmark: local mucosal immunisation improves where standard peripheral TB vaccination fails


The only vaccine available for tuberculosis (TB) today - M.bovis Bacille Calmette-Guérin, or BCG for short - is known to be variably protective in different human populations. In particular, epidemiology studies show that adolescents and adults in high-burden TB areas do not benefit from standard intradermal BCG vaccination at all, whereas on the other hand adult vaccination in low mycobacterial exposure areas can lead to protective immunity.

29 May 2017
A new class of safe and effective adjuvants for vaccination

A new class of safe and effective adjuvants for vaccination


An effective vaccine evokes a powerful immune response against a pathogen, resulting in removal of infiltrating pathogens and prevention of illness.

29 May 2017
Comparable  processes in the brains of a MS marmoset model and MS patients

Comparable processes in the brains of a MS marmoset model and MS patients


In the search for therapies for multiple sclerosis (MS), animal models are still needed. However, new therapies that target specific processes can only be tested in animal models if these processes are comparable between patients and the animal model.

29 May 2017
A new therapy against myasthenia gravis tested in rhesus monkeys

A new therapy against myasthenia gravis tested in rhesus monkeys


Myasthenia gravis is an autoimmune disease in which antibodies disturb the transmission of electrical signals from the nerves to the muscle; This causes weaknesses of the muscles. BPRC researchers have contributed to research into a new therapy for this disease.

16 May 2017
A new typing method to support the conservation of endangered monkeys

A new typing method to support the conservation of endangered monkeys


Worldwide, various monkey species are threatened with extinction. BPRC researchers have developed a typing method that contributes to the maintenance of these species in a animal-friendly manner.

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