News

Page 1 of 17.
In total there are 163 English news articles.

18 August 2017
Genetic code of the monkey malaria parasite Plasmodium cynomolgi deciphered

Genetic code of the monkey malaria parasite Plasmodium cynomolgi deciphered


Plasmodium cynomolgi (P. cynomolgi) is closely related to the people malaria parasite Plasmodium vivax. This parasite causes each year millions of serious illnesses in endemic areas.

18 August 2017
Testing of new innovative HIV vaccines

Testing of new innovative HIV vaccines


The development of an efficacious HIV-1 vaccine remains a global priority to prevent new cases of HIV-1 infection. Of the six HIV-1 efficacy trials to date, only one has demonstrated partial efficacy, and the immune correlates analysis of this trial revealed a role for binding antibodies and antibody Fc mediated effector functions.

18 August 2017
More knowledge of the macaque MHC system

More knowledge of the macaque MHC system


The MHC system plays a central role in the recognition of pathogens. Most genes of the MHC system in humans and monkeys are very variable and can especially in Old World apes, such as macaques, occur in different numbers. Therefore, when testing new therapies for diseases in experimental animals it is important to know the variability and numbers of MHC genes of these animals.

18 August 2017
Bonobos show limited genetic variation in intron 2 of MHC class I

Bonobos show limited genetic variation in intron 2 of MHC class I


MHC class I molecules play a central role in the defense of viruses. The study of the DNA that encodes the MHC can teach us a lot about the effects of pathogens on our immune system.

14 August 2017
No selection against offspring with limited variation in the immune system

No selection against offspring with limited variation in the immune system


There are indications that partner choice of people is unconsciously focused on ensuring a progeny that is well-armed against pathogens. The Major Histocompatibility Complex (MHC) is a component of the immunesystem which plays an important role in the recognition of pathogens.

9 August 2017
Sensorimotor rhythm neurofeedback as an adjuct therapy for Parkinson's Disease

Sensorimotor rhythm neurofeedback as an adjuct therapy for Parkinson's Disease


Despite all the research effort to target neurodegeneration, there is still a lack of satisfactory drug-mediated treatments for Parkinson´s disease. Therefore, there is an urgent need for new treatment modalities such as neurofeedback technology that target diseases of the brain. Neurofeedback is based on neurological compensatory mechanisms that help our brain to adjust to ever-changing conditions, including Parkinson´s disease.

10 July 2017
A renewed and improved database for the genes of the major histocompatibility complex of different animal species

A renewed and improved database for the genes of the major histocompatibility complex of different animal species


Our body must recognize viruses, bacteria and parasites and distinguish these from its tissues to render the pathogens harmless without attacking the own tissues. A very complex part of the immune system is responsible for this, the major histocompatibility complex (MHC).

29 June 2017
BPRC ANNUAL SCIENTIFIC REPORT 2016

BPRC ANNUAL SCIENTIFIC REPORT 2016


We are pleased to present the BPRC 2016 Annual Scientific Report

20 June 2017
The Epstein Barr Virus (EBV) can deregulate the human immune system and cause disease

The Epstein Barr Virus (EBV) can deregulate the human immune system and cause disease


BPRC researchers have previously shown that an EBV-related virus can disrupt the immune system of monkeys  and can therebye cause multiple sclerosis (MS) (http://www.bprc.nl/en/article/infection-with-a-virus-related-to-epstein-barr-dysregulates-the-immune-system-of-monkeys). This work has been described  previously  in the Multiple Sclerosis Journal - Experimental, Translational and Clinical

20 June 2017
Genetic signals from the mother affect gene expression of the unborn child in the placenta

Genetic signals from the mother affect gene expression of the unborn child in the placenta


Each cell in the body contains the same DNA, the genetic code that determines which proteins may be produced by a cell. However, the proteins that are produced differ significantly between cells of different tissues. Similarly, the timing of expression and the expression levels are regulated in a complex manner at different levels. For example, certain molecules such as methyl groups can bind to specific parts of the DNA. Such genetic modification often leads to suppression of the transcription of the gene and the associated protein production.

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